Adult Psychiatric Outcomes of Very Low Birth Weight Survivors
Abstract
Background: Childhood studies have identified relationships between low birth weight and a variety of psychological disorders. However, very few studies have prospectively followed VLBW survivors into adulthood and none have examined adult psychiatric disorders in this population.
Objective: This exploratory study sought to determine the rates and nature of psychiatric disorders in very low birth weight (VLBW, birth weight 2499 g) controls, born 1977–1982, were assessed in early adulthood (24–29 years). Participants were first screened for psychopathology using the Symptoms Checklist (SCL-90-R). Participants who were elevated on this measure were eligible for a Structured Clinical Interview for DSM-IV-TR (SCID-I/NP) to determine a formal psychiatric diagnosis.
Results: VLBW adults were more likely than controls to be elevated on the Global Severity Index (odds ratio (OR) = 4.29, 95% confidence interval (CI) = 0.96, 19.14) and the depression (OR = 5.17, 95%CI = 1.17, 23.00), paranoid ideation (OR = 4.08, 95%CI = 0.91, 18.23), hostility (relative risk (RR) = 1.34, 95%CI = 1.21, 1.49), and interpersonal sensitivity (OR = 3.80, 95%CI = 1.08, 13.32) subscales of the SCL-90-R. VLBW adults were also more likely to be diagnosed with a current mood disorder than NBW adults (RR = 1.36, 95%CI = 1.22, 1.51).
Conclusions: VLBW adults are at greater risk of psychopathology than NBW peers.
Source: University of Melbourne, Melbourne, Victoria, Australia, Royal Women’s Hospital, Melbourne, Victoria, Australia. Murdoch Children’s Research Institute, Melbourne, Victoria, Australia
Royal Children’s Hospital, Melbourne, Victoria, Australia
supported by
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