Withdrawal in newborns after exposure to psychotropic medications during pregnancy

Widodo Judarwanto. Children Allergy Online Clinic, Jakarta Indonesia

Kieviet N, et al. Show all Journal
Ned Tijdschr Geneeskd. 2012;156(16):A4395.

Abstract

The use of psychotropic medications during pregnancy causes withdrawal symptoms in 20-30% of the newborns.- The literature on withdrawal symptoms is not unanimous concerning their recognition and treatment.- A search of PubMed and Embase revealed 198 articles in which potential withdrawal symptoms in newborns were described following exposure to psychotropic medications during pregnancy.- Commonly occurring withdrawal symptoms are mostly mild, including restlessness and sleeping and feeding difficulties. Severe symptoms such as convulsions are rare.- It can sometimes be difficult to differentiate between symptoms of intoxication and symptoms of withdrawal.- The Finnegan scale is widely used to recognise withdrawal from psychotropic medication. An observation period of at least 48 h post-partum is advised. Recognition of withdrawal is important to prevent needless additional tests. – In withdrawal symptoms supportive measures such as feeding on demand and swaddling are usually sufficient. If withdrawal symptoms are severe, phenobarbital is a therapeutic option.

Source: Sint Lucas Andreas Ziekenhuis, Psychiatrie Obstetrie Pediatrie expertisecentrum, Amsterdam.

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