Case Report
Cytokine Dermatitis and Febrile Seizure From Imiquimod
J. Suzanne Mosher, MDa and Peter Lio,
ABSTRACT
Cytokine dermatitis is a well-known and common clinical adverse effect of imiquimod 5% cream (Aldara, 3M). Data from initial Phase III clinical trials reveal a minority of study drug patients experience systemic adverse effects, including fever, arthralgia, headache, myalgia, and lymphadenopathy. These adverse effects are caused, presumably, from increased absorption of study drug over the area of dermatitis, leading to systemic cytokine release. Furthermore, the incidence of systemic reactions was rarely statistically increased above control patients. We describe herein a case of severe cytokine dermatitis in a 2-year-old female patient treated with daily imiquimod for molluscum contagiosum who subsequently developed febrile seizure. We believe this to be the first reported case of seizure associated with imiquimod 5% cream (Aldara, 3M) in a pediatric setting.
KEY WORDS
adverse effect carcinoma fever imiquimod immunomodulator keratosis seizure Toll-like receptor 7 topical
Source : Harvard Vanguard Medical Associates, Watertown, Massachusetts; and Northwestern University, Feinberg School of Medicine, Dermatology & Aesthetics of Wicker Park, Chicago, Illinois
Provided by
CHILDREN ALLERGY CLINIC ONLINE
Yudhasmara Foundation
htpp://www.allergyclinic.wordpress.com/
- CHILDREN GROW UP CLINIC I JL Taman bendungan Asahan 5 Jakarta Pusat, Jakarta Indonesia 10210 Phone : (021) 70081995 – 5703646
- CHILDREN GROW UP CLINIC II MENTENG SQUARE Jl Matraman 30 Jakarta Pusat
Clinical and Editor in Chief :
Dr Widodo Judarwanto, pediatrician email : , Curiculum Vitae
Information on this web site is provided for informational purposes only and is not a substitute for professional medical advice. You should not use the information on this web site for diagnosing or treating a medical or health condition. You should carefully read all product packaging. If you have or suspect you have a medical problem, promptly contact your professional healthcare provider.
Copyright © 2012, Children Allergy Clinic Online Information Education Network. All rights reserved
