The Future Immunoneurobiological Research of Autism Spectrum Disease

Autism (autism spectrum disorders) is a complex, strongly genetically influenced, behaviorally defined disorder of the immature brain associated with very uneven intellectual abilities. Among its most salient and potentially treatable neurologic features disorganized sleep patterns, and sensory and motor deficits. Its many causes and wide range of severity means that there is no symptom, no pathology, imaging, electroencephalography, or other biologic feature, and no biologic treatment that is universal or diagnostic of this developmental syndrome.

References The Future Immunoneurobiological Research of Autism Spectrum Disease

  • Neurobiological basis of autism.
    Silver WG, et al. Pediatr Clin North Am. 2012
  • Elevated transcription factor specificity protein 1 in autistic brains alters the expression of autism candidate genes.
    Thanseem I, et al. Biol Psychiatry. 2012
  • Basal forebrain involvement in low-functioning autistic children: a voxel-based morphometry study.
    Riva D, et al. AJNR Am J Neuroradiol. 2011
  • Modeling the functional genomics of autism using human neurons.
    Konopka G, et al. Mol Psychiatry. 2012
  • Auditory-motor mapping training as an intervention to facilitate speech output in non-verbal children with autism: a proof of concept study.
    Wan CY, et al. PLoS One. 2011
  • Transcranial magnetic stimulation provides means to assess cortical plasticity and excitability in humans with fragile x syndrome and autism spectrum disorder.
    Oberman L, et al. Front Synaptic Neurosci. 2010
  • Pathways underlying the gut-to-brain connection in autism spectrum disorders as future targets for disease management.
    de Theije CG, et al. Eur J Pharmacol. 2011
  • A lack of association between hyperserotonemia and the increased frequency of serum anti-myelin basic protein auto-antibodies in autistic children.
    Mostafa GA, et al. J Neuroinflammation. 2011
  • Increased serum osteopontin levels in autistic children: relation to the disease severity.
    Al-ayadhi LY, et al. Brain Behav Immun. 2011
  • Intrauterine inflammation, insufficient to induce parturition, still evokes fetal and neonatal brain injury.
    Elovitz MA, et al. Int J Dev Neurosci. 2011
  • Increased serotonin axons (immunoreactive to 5-HT transporter) in postmortem brains from young autism donors.
    Azmitia EC, et al. Neuropharmacology. 2011
  • Brief report: “allergic symptoms” in children with Autism Spectrum Disorders. More than meets the eye?
    Angelidou A, et al. J Autism Dev Disord. 2011
  • Immunological characterization and transcription profiling of peripheral blood (PB) monocytes in children with autism spectrum disorders (ASD) and specific polysaccharide antibody deficiency (SPAD): case study.
    Jyonouchi H, et al. J Neuroinflammation. 2012
  • Autoimmune regulator (AIRE) contributes to Dectin-1-induced TNF-α production and complexes with caspase recruitment domain-containing protein 9 (CARD9), spleen tyrosine kinase (Syk), and Dectin-1.
    Pedroza LA, et al. J Allergy Clin Immunol. 2012
  • Cerebrospinal fluid and serum markers of inflammation in autism.
    Zimmerman AW, et al. Pediatr Neurol. 2005
  • Evaluation of an association between gastrointestinal symptoms and cytokine production against common dietary proteins in children with autism spectrum disorders.
    Jyonouchi H, et al. J Pediatr. 2005
  • Dysregulated innate immune responses in young children with autism spectrum disorders: their relationship to gastrointestinal symptoms and dietary intervention.
    Jyonouchi H, et al. Neuropsychobiology. 2005
  • Children with autism spectrum disorders (ASD) who exhibit chronic gastrointestinal (GI) symptoms and marked fluctuation of behavioral symptoms exhibit distinct innate immune abnormalities and transcriptional profiles of peripheral blood (PB) monocytes.
    Jyonouchi H, et al. J Neuroimmunol. 2011
  • Age-dependent changes in peripheral blood dendritic cell subsets in normal children and children with specific polysaccharide antibody deficiency (SPAD).
    Jyonouchi H, et al. Eur J Pediatr. 2010
  • Autism spectrum disorders and allergy: observation from a pediatric allergy/immunology clinic.
    Jyonouchi H, et al. Expert Rev Clin Immunol. 2010
  • Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report.
    Buie T, et al. Pediatrics. 2010
  • Aberrant responses to TLR agonists in pediatric IBD patients; the possible association with increased production of Th1/Th17 cytokines in response to candida, a luminal antigen.
    Jyonouchi H, et al. Pediatr Allergy Immunol. 2010
  • Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder.
    Jyonouchi H, et al. Neuropsychobiology. 2002
  • An orally supplemented mononucleotide mixture prevents the decrease in T cell-dependent humoral immunity in C57BL/6 mice fed a nucleotide-free diet.
    Jyonouchi H, et al. J Nutr. 1996
  • Food allergy and autism spectrum disorders: is there a link?
    Jyonouchi H, et al. Curr Allergy Asthma Rep. 2009
  • Impact of innate immunity in a subset of children with autism spectrum disorders: a case control study.
    Jyonouchi H, et al. J Neuroinflammation. 2008
  • Non-IgE mediated food allergy.
    Jyonouchi H, et al. Inflamm Allergy Drug Targets. 2008
  • Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder.
    Jyonouchi H, et al. Neuropsychobiology. 2002
  • Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression.
    Jyonouchi H, et al. J Neuroimmunol. 2001

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